Closer to home
Bring professionally guided treatment into daily routines.
NON-INVASIVE NEUROMODULATION · CONNECTED MANAGEMENT
Care,closer to everyday life
Zentrix is building a platform of non-invasive neuromodulation and digital therapeutics—starting with overactive bladder and designed to expand into broader everyday health needs.
Intelligent neuromodulation for everyday health
OUR PURPOSE
Care should not stopat the hospital door
Chronic symptoms follow people into every part of life. We believe professional care should be able to follow them too—quietly, respectfully and with less disruption.
Built for dignity
Design discreet experiences around real people, not just clinical settings.
Connected over time
Turn home therapy and symptom records into more structured follow-up.
UNDERSTANDING OAB
Common, disruptiveand too often managedin silence
Overactive bladder, or OAB, is defined by a sudden and difficult-to-defer need to urinate. It is usually accompanied by frequency and nocturia, and may occur with or without urgency urinary incontinence.
people worldwide
were estimated to experience OAB symptoms by 2018
Irwin et al., BJU International, 2011of adults aged 40+ in China
met the study definition of OAB in a population-based survey
Wang et al., Medicine, 2018Prevalence varies by population, age and study definition. These figures describe published epidemiology, not the addressable market for WisePulse.
THE UNMET NEED
OAB is more thana bladder problem
Overactive bladder can interrupt sleep, travel, work and confidence. Some people remain undertreated because existing options may involve tolerability concerns, repeated clinic visits, invasive procedures or the burden of staying consistent over time.
OAB symptoms should be assessed by a qualified healthcare professional. Similar symptoms may have other causes.
Urgency
A sudden, difficult-to-defer need to urinate
Frequency
Urinating more often than feels normal
Nocturia
Waking at night to urinate
UUI
Leakage associated with urgency
OUR FLAGSHIP PROGRAM
Life, back in rhythm
WisePulse is a clinician-guided, non-invasive wearable TTNS system designed for home-based OAB management.
Place with confidence · Treat with ease · See your progress
Guided placement
A positioning patch and optimized electrode architecture are designed to support more consistent application.
Simple home therapy
Compact, discreet treatment designed to fit more naturally into everyday routines.
Connected progress
Session, adherence and symptom records support more structured follow-up.
Professional, connected home therapy—designed to be more accessible and sustainable.
HOW TTNS WORKS
The neuromodulation principle of PTNSdelivered without a needle
TTNS delivers gentle electrical stimulation through surface electrodes near the tibial nerve at the ankle. The stimulation travels along nerve pathways connected with the bladder control system and is intended to support better regulation of bladder signals.
01
Surface stimulation
Electrodes are positioned on the skin near the ankle.
02
Tibial nerve pathways
Afferent signals travel along the tibial nerve.
03
Sacral pathways
These pathways share spinal segments involved in bladder control.
04
Bladder signal regulation
Neuromodulation aims to influence abnormal storage and urgency signals.
The precise mechanism of tibial nerve stimulation is not fully understood. Individual response varies, and regular treatment and clinical follow-up may be required.
CONNECTED MANAGEMENT
Home therapyconnected toprofessional follow-up
The WisePulse digital experience is being designed to guide setup, record therapy, capture bladder symptoms and make follow-up conversations more informed.
Guided setup
Clear in-app instructions support confident use at home.
Treatment adherence
Session history helps distinguish incomplete use from limited response.
Bladder diary
Track urgency, frequency, nocturia and leakage over time.
Structured follow-up
Relevant trends can support clinician–patient review.
ROADMAPRoadmap: data-informed personalized programs under clinician guidance
9:41
⌁WisePulse
Good morning
Today’s therapy
30MIN
Ready to beginPROGRAM 01
Next review08 · 24
APP CONCEPT · UI SUBJECT TO CHANGE
CLINICAL FOUNDATION
Evidence-ledwith clear boundaries
The evidence below relates to tibial nerve stimulation and TTNS as therapeutic modalities—not to clinical outcomes generated specifically with WisePulse.
CLINICAL GUIDANCE01
Tibial nerve stimulation is included in international OAB guidance
EAU guidance discusses percutaneous and transcutaneous tibial nerve stimulation as options for improving OAB and urgency urinary incontinence symptoms.
EAU GuidelinesSYSTEMATIC REVIEW02
Published reviews report improvement signals across core OAB symptoms
A systematic review reported supportive signals for urgency, frequency, nocturia and incontinence, while noting substantial variation in protocols and study quality.
Booth et al., 2018COMPARATIVE EVIDENCE03
Selected studies report similar TTNS and PTNS outcomes in several endpoints
A small meta-analysis found no statistically significant differences in several reported bladder-diary and quality-of-life outcomes. Evidence certainty remains limited; this is not proof of formal equivalence.
Yang et al., 2021WEARABLE DELIVERY04
Home-based wearable TTNS has been studied against sham stimulation
A multicentre randomized study supports the feasibility of a wearable, app-controlled home TTNS approach. The study evaluated another device, not WisePulse.
Liao et al., 2024What this evidence does—and does not—say
Published modality evidence can support the rationale for TTNS. It does not establish WisePulse-specific efficacy, superiority, precision, safety or regulatory authorization. Product claims will be aligned with WisePulse-specific data and locally approved labeling.
A REPLICABLE PLATFORM
One platforma broader visionfor everyday health
Zentrix is combining wearable stimulation, application guidance and connected management into a platform intended to extend across multiple needs—without losing sight of disciplined evidence generation.
1
NOW
Overactive bladder
Our first focus: clinician-guided home TTNS for long-term OAB management.
2
NEXT
Dysmenorrhea
A future application of the same non-invasive neuromodulation and digital-care platform.
3
FUTURE
Everyday health
Selected consumer-health needs where wearable neuromodulation can create meaningful, responsible value.
INNOVATION ECOSYSTEM
Incubated by the3DEXPERIENCE Lab
Zentrix is an incubated company of the 3DEXPERIENCE Lab, Dassault Systèmes—part of an open innovation ecosystem that helps ambitious projects move toward real-world impact.
Program relationship does not imply endorsement of WisePulse-specific clinical, regulatory or commercial claims.
Visit 3DEXPERIENCE LabBUILT TO EXECUTE
A team thatunderstands howmedtech moves
Our team combines medical-device R&D, clinical translation, commercialization and cross-border market development. Prior professional experience spans global and Asian medtech organizations and healthcare networks.
COLLECTIVE EXPERIENCE
Experience across leading global and Asian medtech organizations, supported by INSEAD education.
Company names are provided solely to describe prior individual experience and do not imply endorsement, partnership or affiliation with Zentrix.BUILD THE NEXT STANDARD WITH US
Let’s bring responsibleneuromodulation closerto everyday life
We welcome conversations with clinicians, research partners, distributors and investors who share our commitment to evidence-led, accessible healthcare.
Start a conversation